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Many lines of evidence suggest that LDL is oxidized in vivo and that Ox-LDL is present in the artery wall. But the oxidation of VLDL and HDL in vivo has not been reported yet. A study on oxidative modification of serum LDL, VLDL, HDL in patients with endogenous hypertriglyceridemia (HTG) and in rabbits fed on high cholesterol diet was made. The serum LDL, VLDL and HDL were isolated by the density...
The arterial smooth muscle cells (SMC) are the predominant type of cells within atherosclerotic (As) lesions, and their proliferation plays an important role in the process of As genesis. The effect of LDL, VLDL, HDL, OX-LDL, OX-VLDL, OX-HDL on the proto-oncogenes expression and DNA synthesis of cultured human SMC were observed. Results are as follows: 1. HDL had no effects on the expression of...