Search results for: Ilker Uçkay

Items from 1 to 20 out of 60 results

article

Interventions in the management of diabetes‐related foot infections: A systematic review

Edgar J. G. Peters, Zaina Albalawi, Suzanne A. Asten, Zulfiqarali G. Abbas, more

Diabetes/Metabolism Research and Reviews > 40 > 3 > n/a - n/a

The optimal approaches to managing diabetic foot infections remain a challenge for clinicians. Despite an exponential rise in publications investigating different treatment strategies, the various agents studied generally produce comparable results, and high‐quality data are scarce. In this systematic review, we searched the medical literature using the PubMed and Embase databases for published studies...

article

IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes‐related foot infections (IWGDF/IDSA 2023)

Éric Senneville, Zaina Albalawi, Suzanne A. Asten, Zulfiqarali G. Abbas, more

Diabetes/Metabolism Research and Reviews > 40 > 3 > n/a - n/a

The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the management and prevention of diabetes‐related foot diseases since 1999. The present guideline is an update of the 2019 IWGDF guideline on the diagnosis and management of foot infections in persons with diabetes mellitus. The Grading of Recommendations, Assessment, Development, and Evaluation...

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Diagnosis of infection in the foot of patients with diabetes: A systematic review

Éric Senneville, Zaina Albalawi, Suzanne A. Asten, Zulfiqarali G. Abbas, more

Diabetes/Metabolism Research and Reviews > 40 > 3 > n/a - n/a

Background Securing an early accurate diagnosis of diabetic foot infections and assessment of their severity are of paramount importance since these infections can cause great morbidity and potential mortality and present formidable challenges in surgical and antimicrobial treatment. Methods In June 2022, we searched the literature using PubMed and EMBASE for published studies on the diagnosis...

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Assessment and management of diabetes‐related foot infection according to the new International Working Group on the Diabetic Foot guidelines 2023—Multidisciplinary grand rounds

Kay Hon, Frank Nobels, Éric Senneville, Ilker Uckay, more

Diabetes/Metabolism Research and Reviews > 40 > 3 > n/a - n/a

Diabetes‐related foot disease is a serious and common complication for people with diabetes mellitus. The gold standard care for a person with diabetes‐related foot disease is the involvement of a multidisciplinary foot team engaged in evidence‐based care. To date, there are seven International Working Group on the Diabetic Foot (IWGDF) guidelines published to assist healthcare providers in managing...

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Initial antibiotic therapy for postoperative moderate or severe diabetic foot infections: Broad versus narrow spectrum, empirical versus targeted

Arend J. Nieuwland, Felix W. A. Waibel, Andreas Flury, Marcus Lisy, more

Diabetes, Obesity and Metabolism > 25 > 11 > 3290 - 3297

Aim To retrospectively evaluate clinical and microbiological outcomes after combined surgical and medical therapy for diabetic foot infections (DFIs), stratifying between the empirical versus the targeted nature, and between an empirical broad versus a narrow‐spectrum, antibiotic therapy. Methods We retrospectively assessed the rate of ultimate therapeutic failures for each of three types of initial...

article

Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

Truong‐Thanh Pham, Diego O. Andrey, Susanne Stampf, Sara H. Burkhard, more

American Journal of Transplantation > 22 > 12 > 3031 - 3046

Bone and joint infection (BJI) epidemiology and outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI in a multi‐center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive SOTr with BJI (01.05.2008–31.12.2019) were included. A nested case–control study to identify risk factors for BJI was performed. Among 4482 patients, 61 SOTr with 82 BJI...

article

Is routine measurement of the serum C‐reactive protein level helpful during antibiotic therapy for diabetic foot infection?

Truong‐Thanh Pham, Oliver Wetzel, Karim Gariani, Benjamin Kressmann, more

Diabetes, Obesity and Metabolism > 23 > 2 > 637 - 641

Clinicians frequently monitor serum C‐reactive protein (CRP) levels during therapy for diabetic foot infections (DFIs), but evidence supporting this is unclear. Using a database from prospective controlled DFI trials, with fixed duration of antibiotic therapy, we correlated the CRP levels at study enrolment and at end of therapy (EOT). Among 159 DFI episodes, 93 involved the bone and 66 the soft tissues...

article

Oral amoxicillin‐clavulanate for treating diabetic foot infections

Karim Gariani, Dan Lebowitz, Benjamin Kressmann, Elodie von Dach, more

Diabetes, Obesity and Metabolism > 21 > 6 > 1483 - 1486

Aim To assess amoxicillin‐clavulanate (AMC) for the oral therapy of diabetic foot infections (DFIs), especially for diabetic foot osteomyelitis (DFO). Methods We performed a retrospective cohort analysis among 794 DFI episodes, including 339 DFO cases. Results The median duration of antibiotic therapy after surgical debridement (including partial amputation) was 30 days (DFO, 30 days). Oral AMC...

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Remission in diabetic foot infections: Duration of antibiotic therapy and other possible associated factors

Karim Gariani, Dan Lebowitz, Elodie von Dach, Benjamin Kressmann, more

Diabetes, Obesity and Metabolism > 21 > 2 > 244 - 251

Aim To determine the most appropriate duration of antibiotic therapy for diabetic foot infections (DFIs). Methods Using a clinical pathway for adult patients with DFIs (retrospective cohort analysis), we created a cluster‐controlled Cox regression model to assess factors related to remission of infection, emphasizing antibiotic‐related variables. We excluded total amputations as a result of DFI...

article

Should antibiotic prophylaxis before orthopedic implant surgery depend on the duration of pre-surgical hospital stay?

Marie Davat, Lydia Wuarin, Dimitrios Stafylakis, Mohamed Abbas, more

Antimicrobial Resistance & Infection Control > 2018 > 7 > 1 > 1-7

Background Prolonged hospital stay before surgery is a risk for colonization with antibiotic-resistant microorganisms and possible antibiotic-resistant surgical site infections (SSI), which lacks acknowledgement in international guidelines for perioperative antibiotic prophylaxis. Method Retrospective cohort study focusing on prophylaxis-resistant SSI in adult orthopedic implant patients; with emphasis...

article

A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection

Ilker Uçkay, Benjamin Kressmann, Sarah Malacarne, Anna Toumanova, more

BMC Infectious Diseases > 2018 > 18 > 1 > 1-9

Background An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI). Methods Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI. Results We included 88 DFUI episodes with 43 patients...

article

Native septic arthritis is not an immediate surgical emergency

Nicolas Lauper, Marie Davat, Ergys Gjika, Camillo Müller, more

Journal of Infection > 2018 > 77 > 1 > 47-53

Acute native joint septic arthritis is generally considered a surgical emergency, requiring drainage within hours, including during night, weekend or holiday shifts. However, there are few data supporting the need for the disruption caused by this degree of urgency. We performed a retrospective review of all adult patients seen in our medical center from 1997−2015 with culture-proven septic arthritis...

article

Is There an Association Between Smoking Status and Prosthetic Joint Infection After Primary Total Joint Arthroplasty?

Amanda I. Gonzalez, Jolanda J. Luime, Ilker Uçkay, Didier Hannouche, more

The Journal of Arthroplasty > 2018 > 33 > 7 > 2218-2224

Recent reports highlighted the association between smoking and higher risk of postsurgical infections. The aim was to compare the incidence of prosthetic joint infection after primary total joint arthroplasty (TJA) according to smoking status.A prospective hospital registry–based cohort study was performed including all primary knee and hip TJAs performed between March 1996 and December 2013. Smoking...

article

Antibiotic therapy duration for prosthetic joint infections treated by Debridement and Implant Retention (DAIR): Similar long-term remission for 6 weeks as compared to 12 weeks

Hélène Chaussade, Ilker Uçkay, Albert Vuagnat, Jérôme Druon, more

International Journal of Infectious Diseases > 2017 > 63 > C > 37-42

The required duration of antibiotic treatment for prosthetic joint infections (PJI) with debridement and retention of the implant (DAIR procedure) is unknown.Multicenter retrospective study emphasizing the duration of antibiotic therapy in patients treated with by DAIR.We included 87 hip or knee PJI episodes in 87 patients from three university hospitals in France and Switzerland. All debridements...

article

Enterococci in orthopaedic infections: Who is at risk getting infected?

Ilker Uçkay, Daniela Pires, Americo Agostinho, Nastassia Guanziroli, more

Journal of Infection > 2017 > 75 > 4 > 309-314

Some orthopaedic patients might be at risk for enterococcal infections and might benefit from adapted perioperative prophylaxis.We performed a single-center cohort of adult patients with orthopaedic infections.Among 2740 infection episodes, 665 surgeries (24%) involved osteosynthesis material, including total joint arthroplasties. The recommended perioperative prophylaxis was cefuroxime (or vancomycin...

article

A case report of CT-diagnosed renal infarct secondary to syphilitic aortitis

Maaike Spaltenstein, Françoise Humbert, Diem-Lan Vu, Ilker Uçkay, more

BMC Infectious Diseases > 2017 > 17 > 1 > 1-4

Background Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquired before the advent of relatively modern technologies such as CT, MRI and PET. This case report presents a rare case of syphilitic aortitis associated with a renal infarct caused...

article

One- vs 2-Stage Bursectomy for Septic Olecranon and Prepatellar Bursitis

Ilker Uçkay, Elodie von Dach, Cédric Perez, Americo Agostinho, more

Mayo Clinic Proceedings > 2017 > 92 > 7 > 1061-1069

To assess the optimal surgical approach and costs for patients hospitalized with septic bursitis.From May 1, 2011, through December 24, 2014, hospitalized patients with septic bursitis at University of Geneva Hospitals were randomized (1:1) to receive 1- vs 2-stage bursectomy. All the patients received postsurgical oral antibiotic drug therapy for 7 days.Of 164 enrolled patients, 130 had bursitis...

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Staphylococcus aureus soft tissue infection may increase the risk of subsequent staphylococcal soft tissue infections

Cindy Bouvet, Shpresa Gjoni, Besa Zenelaj, Benjamin A. Lipsky, more

International Journal of Infectious Diseases > 2017 > 60 > C > 44-48

Staphylococcus aureus is the most common cause of soft tissue infections. It is unknown, however, if a patient who has had such an infection is at greater risk for future soft tissue infections with S. aureus.We conducted an epidemiological survey of adult patients hospitalized in the only public hospital in Geneva for treatment (usually combined surgical and medical) of a soft tissue infection caused...

article

Are antibiotic-resistant pathogens more common in subsequent episodes of diabetic foot infection?

Dan Lebowitz, Karim Gariani, Benjamin Kressmann, Elodie von Dach, more

International Journal of Infectious Diseases > 2017 > 59 > C > 61-64

After antibiotic therapy of an initial diabetic foot infection (DFI), pathogens isolated from subsequent episodes might become more resistant to commonly prescribed antibiotics. If so, this might require a modification of the current recommendations for the selection of empiric antibiotic therapy. This study investigated whether the Infectious Diseases Society of America (IDSA) DFI guideline recommendations...

article

Clinical and epidemiological differences between implant-associated and implant-free orthopaedic infections

Céline Cuérel, Sophie Abrassart, Julien Billières, Diego Andrey, more

European Journal of Orthopaedic Surgery & Traumatology > 2017 > 27 > 2 > 229-231

Purpose Although there have been many publications regarding the risk factors for implant-associated orthopaedic infections, none have investigated how clinical presentations and epidemiology may differ between infections with and without osteosynthetic material. Methods We pooled clinical data from several databases of adult patients with orthopaedic infections hospitalized at Geneva University...

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INFONA - science communication portal

Search results for: Ilker Uçkay

Interventions in the management of diabetes‐related foot infections: A systematic review

IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes‐related foot infections (IWGDF/IDSA 2023)

Diagnosis of infection in the foot of patients with diabetes: A systematic review

Assessment and management of diabetes‐related foot infection according to the new International Working Group on the Diabetic Foot guidelines 2023—Multidisciplinary grand rounds

Initial antibiotic therapy for postoperative moderate or severe diabetic foot infections: Broad versus narrow spectrum, empirical versus targeted

Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

Is routine measurement of the serum C‐reactive protein level helpful during antibiotic therapy for diabetic foot infection?

Oral amoxicillin‐clavulanate for treating diabetic foot infections

Remission in diabetic foot infections: Duration of antibiotic therapy and other possible associated factors

Should antibiotic prophylaxis before orthopedic implant surgery depend on the duration of pre-surgical hospital stay?

A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection

Native septic arthritis is not an immediate surgical emergency

Is There an Association Between Smoking Status and Prosthetic Joint Infection After Primary Total Joint Arthroplasty?

Antibiotic therapy duration for prosthetic joint infections treated by Debridement and Implant Retention (DAIR): Similar long-term remission for 6 weeks as compared to 12 weeks

Enterococci in orthopaedic infections: Who is at risk getting infected?

A case report of CT-diagnosed renal infarct secondary to syphilitic aortitis

One- vs 2-Stage Bursectomy for Septic Olecranon and Prepatellar Bursitis

Staphylococcus aureus soft tissue infection may increase the risk of subsequent staphylococcal soft tissue infections

Are antibiotic-resistant pathogens more common in subsequent episodes of diabetic foot infection?

Clinical and epidemiological differences between implant-associated and implant-free orthopaedic infections

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