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Objective: The role of oral immunosuppressive therapy (OIT) to prevent restenosis after percutaneous coronary intervention (PCI) and stenting is still controversial. This study evaluates the impact of oral administration of prednisone or sirolimus to prevent restenosis. Methods: We conducted a meta-analysis of trials in which PCI-patients were randomized to bare metal stents (BMS) plus OIT (BMS +...
Aims We examined the clinical characteristics and outcome of patients with early (<2h), intermediate (2-4h) and late (>4h) presentation treated by primary angioplasty or thrombolytic therapy for acute myocardial infarction. Methods and Results We studied 2635 patients enrolled in 10 randomized trials of primary angioplasty (n=1302) vs thrombolytic therapy (n=1333) in acute myocardial infarction,...
Background: Aortic valve resistance (AVR) has been recently emphasized as a possible flow-independent index of aortic stenosis (AS) severity. There are, however, few studies in small groups of patients (pts), in which AVR has been compared to aortic valve area (AVA) in order to establish reliable cut-off values of severity. Furthermore it is yet unknown if AVR may provide adjunctive clinical information...
Primary (P) PTCA is a logistically demanding therapeutic option; identification of AMI patients (pts) in whom P-PTCA is most beneficial is important to optimize both AMI treatment and P-PTCA use. Anterior ST depression (ASTD) in inferior AMI is a marker of poor prognosis, but little is known about the long-term outcome of P-PTCA and t-PA in these pts. One-month results from our study in 110 pts randomized...
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