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Abstract The cerebrospinal fluid (CSF) of patients with Guillain-Barr syndrome (GBS) contains a low molecular weight factor with sodium channel blocking activity. This study investigated whether such activity also exists in the CSF of patients with other neurological diseases. Further, using high-performance liquid chromatography (HPLC) we tested whether the electrophysiological effect of the CSF...
The cerebrospinal fluid (CSF) of patients with multiple sclerosis or Guillain-Barre syndrome contains a factor that inhibits excitation of nerve and muscle cells like local anesthetics. CSF samples containing the endogenous local anesthetic-like factor (ELLF) were analyzed by gel filtration chromatography and ultraviolet (UV) absorption at 210 nm. The active component was in a single peak corresponding...
Sodium channel blockade by antibodies or other factors was recently suggested as a new mechanism of neurological disease [Waxman, Ann Neurol 37:421-423, 1995]. We could show that the CSF of patients with Guillain-Barre[acute ] syndrome (GBS) [Brinkmeier et al. Pflu[uml ]gers Arch 421:552-557, 1992], multiple sclerosis (MS), or chronic inflammatory demyelinating polyneuropathy (CIDP) [Wu[uml ]rz...
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