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IgG 2 antibodies are the main antibody subclass produced after pneumococcal polysaccharide vaccination. For these antibodies to be effective, interaction with FcγIIa receptors on phagocytic cells is necessary. FcγRIIa displays a functional polymorphism with either a histidine (H) or arginine (R) at position 131. Interaction of IgG 2 antibodies depends on the H131 allele, whereas this...
A guanine to adenine point mutation results in an arginine (R) to histidine (H) substitution in FcγRIIa at residue 131 that strongly impacts receptor function. This FcγRIIa polymorphism is mostly typed by allele-specific polymerase chain reactions (PCR) or in functional assays, dependent on ligand binding. Both types of methods are laborious, time consuming, and not readily available in routine laboratories...
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