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Background & Aims: Duodenal bicarbonate secretion is in part mediated by an apical Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down-regulated in adenoma) gene encodes a transport protein (DRA) for SO42−, Cl−, and HCO3−. The aim of this study was to investigate whether DRA may be the duodenal apical Cl−/HCO3− exchanger. Methods: DRA, Na+/H+ exchanger (NHE) isoform...
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