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Off-line sample prefractionations applied prior to biomarker discovery proteomics are options to enable more protein identifications and detect low-abundance proteins. This work compared five commercial methods efficiency to raw serum analysis using label-free proteomics. The variability of the protein quantities determined for each process was similar to the unprefractionated serum. A 49% increase...
MALDI in‐source decay (ISD) was first introduced in 1995 in a landmark paper by RS Brown and JJ Lenon (Anal. Chem. 1995, 67, 3990–3999). Although MALDI MS is considered a soft ionization technique which enables the analysis of high molecular weight proteins exceeding several hundred kDa in an intact manner, it became apparent that some analyte fragmentation occurs on a very short time scale during...
We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex-DNA binding affinity and quadruplex- over duplex-DNA selectivity of putative ligands. This assay is based on the loss of fluorescence upon displacement of thiazole orange from quadruplex- and duplex-DNA matrices. The original protocol was tested using various quadruplex-...
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