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BACKGROUND:Previous reports from these authors found that activation of peroxisome proliferator‐activated receptor gamma (PPARγ) suppressed hepatocellular carcinoma (HCC). This study sought to identify the molecular target of PPARγ and characterize its antitumor effect in HCC.
METHODS:Optimal PPARγ binding activity was obtained using the PPARγ agonist rosiglitazone (100 μM) as determined by enzyme‐linked...
BACKGROUND:Aberrant methylation of tumor‐related genes has been reported in Epstein‐Barr virus (EBV)‐associated gastric cancers. This study sought to profile EBV‐driven hypermethylation in EBV‐infected cells.
METHODS:The EBV‐positive AGS gastric cancer cell line (AGS‐EBV) and EBV‐negative AGS cells were used in this study. DNA methyltransferase‐3b (DNMT3b) activity was assessed by EpiQuick activity...
BACKGROUND:By using genome‐wide methylation screening, the authors identified ring finger protein 180 (RNF180) as preferentially methylated in cancer. This study was undertaken to clarify its structure and functional role in gastric cancer.
METHODS:The transcription start site and core functional promoter region of RNF180 were revealed by 5′ rapid amplification of cDNA ends and luciferase activity...
BACKGROUND:The role of Epstein‐Barr virus (EBV) infection in gastric carcinogenesis remains largely unknown. The authors studied the effects of zinc finger E‐box binding factor 1 (ZEB1) on latent‐lytic switch of EBV infection in gastric cancer and explored the importance of EBV in gastric carcinogenesis.
METHODS:Loss or gain of ZEB1 function was obtained by ZEB1 small‐interfering RNA (siRNA) knock‐down...
Although peroxisome proliferator‐activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in hepatocarcinogenesis remains unclear. We investigated the therapeutic efficacy of PPARγ against HCC. PPARγ‐deficient (PPARγ+/−) and wild‐type (PPARγ+/+) littermates were used in a diethylnitrosamine (DEN)‐induced HCC model and treated...
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