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INTRODUCTION: Perseveration is defined as a tendency to respond persistently to a particular stimulus, even after the response has become inappropriate. Increased perseveration is associated with aging in humans and leads to impaired ability to cope with problems. Aging is also associated with progressing dysfunction of cholinergic system, which is associated with various cognitive processes. AIM(S):...
Transcriptome profiling of chronic social stress (CSS) effects on the brain revealed changes in expression of many genes responsible for alterations of structure and function of the central nervous system. However, there is still little information on dynamics of gene expression in the brain during chronic stress. The aim of the study was to investigate the time course of mouse hippocampal transcriptome...
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