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An involvement of one particular neurotrophin, namely, the brain-derived neurotrophic factor (BDNF), has been demonstrated in the pathophysiology Huntington’s disease. Type-1 cannabinoid (CB1) receptor has been postulated to upregulate BDNF gene transcription.To better understand the relationship between CB1 and BDNF levels in a situation where the striatum is degenerating, we studied, by dual label...
Shc family of adaptor molecules has been demonstrated to play an important role during the transition from proliferating neural stem cells to postmitotic neurons. Previous studies from our group demonstrated a progressive decrease of ShcA levels occurring in coincidence with the end of embryonic neurogenesis and neuronal maturation, being ShcB and ShcC the major Shc molecules expressed in the mature...
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