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It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal...
Objectives: To provide a revised version of earlier guidelines published in 2006.
Background: Primary dystonias are chronic and often disabling conditions with a widespread spectrum mainly in young people.
Diagnosis: Primary dystonias are classified as pure dystonia, dystonia plus or paroxysmal dystonia syndromes. Assessment should be performed using a validated rating scale for dystonia. Genetic...
Despite of widespread abuse and the presence of vast data about ethanol’s adverse effects on behavior, brain morphology and physiology, molecular mechanism underlying deteriorating effects of chronic ethanol intoxication on the nervous system still remain elusive. The aim of the present study is revisiting the potential effects of adult alcohol insult and/or withdrawal on the protein, nucleic acids,...
Diclofenac sodium (DS) acts as a potent cyclooxygenase inhibititor, reducing arachidonic acid release and prostaglandins formation. It is commonly used as a non-steroid anti-infl ammatory drug and the potential adverse effects of its administration during pregnancy are of medical and public concern. In the present study, the DS in a dose of 1 mg/kg/day was subcutaneously injected to the pregnant Wistar...
Nitric oxide can promote or inhibit apoptosis depending on the cell type and coexisting metabolic or experimental conditions. We examined the impact of nitric oxide on development of apoptosis 6, 24, and 72 h after permanent middle cerebral artery occlusion in mutant mice that lack the ability to generate nitric oxide from neuronal nitric oxide synthase. Adjacent coronal sections passing through the...
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