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The aim of this study was to determine histotopography and age-related changes of immunoreactive substance P (SP-IR) nerve plexus in dog cornea. In this research corneas of three groups of dogs of different age were used: young (2-3 months), adult (1-3 years) and old (8 and more years). Immunohistochemical demonstration of SP was performed on 40 um serial free-floating corneal sections cut parallel...