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Nicotine, the main psychoactive ingredient in tobacco, readily crosses the placental barrier to cause growth and neurobehavioral abnormalities in the offspring. The current study was designed to assess whether nicotinic action causes long lasting teratogenic effects and synaptic dysfunctions. Pregnant Sprague–Dawley rats were infused with nicotine via osmotic minipumps at a dose of 6mg/kg/day corresponding...
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