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Vanadium V (salen) complex 3 has been found to be an effective catalyst for the asymmetric addition of hydrogen cyanide (generated in situ from trimethylsilyl cyanide) to imines. The best results (up to 81% enantiomeric excess) were obtained for aromatic imines in which the nitrogen atom is protected with a benzyl group and in which the imine bond is not sterically encumbered.
A bimetallic titanium(salen) complex 1 was found to catalyse the asymmetric addition of ethyl cyanoformate to aldehydes. Best results were obtained using 5mol% of the catalyst at −40°C and under these conditions, both aromatic and aliphatic aldehydes were converted into cyanohydrin carbonates with up to 99% enantiomeric excess. The same catalyst could also be used to catalyse the asymmetric addition...
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