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Foot-and-mouth disease virus (FMDV) isolate C 1 -Barcelona (or C-S30) includes four replacements within its immunodominant site (GH loop, residues 136-150 of capsid protein VP1, YTTSTRGDLAHVTAT), relative to reference strain C-S8c1 (YTASARGDLAHLTTT). Although one of the mutations in C-S30 ( 147 Leu->Val) is known to be detrimental for antibody recognition, reactivity of...
A foot-and-mouth disease virus (FMDV) field variant, isolate C-S30 (also named C 1 -Barcelona), is known to contain four changes within the main antigenic site A (GH loop of capsid protein VP1, residues 136–150), at least one of which (Leu147→Val) involves a highly conserved position, critical for antibody recognition in the reference strain C-S8c1. However, immunoenzymatic analysis of FMDV...
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