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Effective and rapid treatment of tularemia is needed to reduce morbidity and mortality of this potentially fatal infectious disease. The etiologic agent, Francisella tularensis, is a facultative intracellular bacterial pathogen which infects and multiplies to high numbers in macrophages. Nanotherapeutics are particularly promising for treatment of infectious diseases caused by intracellular pathogens,...
The drug trapping and intracellular release mechanism of redox‐responsive disulfide snap‐top mesoporous silica nanoparticles (MSN‐SS‐MXF) is depicted by J. I. Zink, M. A. Horwitz and co‐workers on page 3690. Mesoporous silica nanoparticles with antibiotic (cyan) trapped within their pores by disulfide snap‐tops are avidly ingested by macrophages. The intracellular redox potential reduces the disulfide...
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