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Trifluoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase activity, probably resulting from the transformation of the fluorinated compounds into their corresponding...
The efficient preparation of α-fluoro-β, γ-alkenylphosphonate3, via catalytic hydrogenation of (α-fluoropropargyl)phosphonate ester1, is described. Conjugated fluoroenynes4 have been synthesized using a modified Horner Wadsworth Emmons (HWE) olefination of aldehydes or ketones and1 in relatively good yields. Yields were lowered because of the formation of α-fluoro-γ-hydroxyallenylphosphonate5 during...
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