The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
A large series of analogues of Eunicea cembranolides 1–3 were synthesized with the purpose of evaluating their cytotoxicity against 60 human cancer cell-lines. Most of the analogues were as active as the lead compounds and a few displayed increased cytotoxicity. Their syntheses were based on the specific reactivity and stereochemistry of the epoxide substructure and involved highly regio- and diastereoselective...
3,7-Diiodo-4,8-epoxy-euniolide (2) was synthesized from euniolide (1) by the addition reaction of iodine in the presence of triphenylphosphine in CH2Cl2. The absolute structure of 2 was unambiguously determined by a combination of 1H and 13C NMR, HREI mass spectroscopy, and x-ray single crystal analysis as (11E, 1S, 3S, 4R, 7S, 8R, 14S)-3,7-diiodo-4,8-epoxy-cembra-11,15-dien-16,14-olide. X-ray crystallographic...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.