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Cancer cells are dependent on protein quality‐control mechanisms, including protein chaperones, the ubiquitin‐proteasome system, and autophagy. The p62 receptor is a classical, ubiquitously expressed receptor, involved in many signal transduction pathways. Upregulation and/or reduced degradation of p62 have been implicated in tumor formation and resistance to therapy. PTX80 is a first‐in‐class novel...
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