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Follicular dendritic cells (FDCs) play a crucial role in generating high‐affinity antibody‐producing B cells during the germinal center (GC) reaction. Herein, we analysed the altered gene expression profile of a mouse FDC line, FL‐Y, following lymphotoxin β receptor stimulation, and observed increased Slam‐family member 8 (Slamf8) mRNA expression. Forced Slamf8 expression and SLAMF8‐Fc addition enhanced...
Calcium/calmodulin‐dependent protein kinase kinases (CaMKKs) activate CaMKI, CaMKIV, protein kinase B/Akt, and AMP‐activated protein kinase (AMPK) by phosphorylating Thr residues in activation loops to mediate various Ca2+‐signaling pathways. Mammalian cells expressing CaMKKα and CaMKKβ lacking Arg/Pro‐rich insert domain (RP‐domain) sequences showed impaired phosphorylation of AMPKα, CaMKIα, and CaMKIV,...