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HIV-1 integrase (IN) has become an important target for antiviral drug discovery. While AIDS drug treatment often fails due to the emergence of drug resistant species. Elvitegravir (EVG) is one of the FDA-approved drugs. We developed a neural network prediction model to make a qualitative EVG resistance phenotype prediction. First, we developed a genotype-phenotype database. Secondly, we classified...
The propagation methods of viruses are diverse and studying the virus propagation is a hot topic. There appears a new way that the search engine quickly spreads network viruses, and many researches overlook its impact of propagation and few researches set a model to quantifiabely analyze how the search engine spread viruses. Based on community networks, this paper designs a specific model how the...
Preventing viruses from spreading in networks is a hot topic. Existing works designed immune strategies for static networks, which become invalid for temporal networks due to their dynamic characteristics and community structure. In this paper, taking into consideration of the evolutionary communities, we propose an evolutionary virus immune strategy for temporal networks. First, we define a new metric,...
Silver-enhanced labeling is a technique used in immunochromatographic assays for improving the sensitivity of pathogen detection. In this paper, we employ the silver enhancement approach for constructing a biomolecular transistor that uses a high-density interdigitated electrode to detect rabbit IgG. We show that the response of the biomolecular transistor comprises of: (a) a sub-threshold region...
Silver-enhanced labeling method that is employed in immunochromatographic assay provides an effective way of improving the sensitivity of detecting pathogens. In this paper, we apply the silver enhancement approach for providing signal amplification in conductimetric biochips which employ gold nanoparticles to bridge on a high-density microelectrode array for detecting gold nanoparticles. One of the...
Advances in micro-nano-biosensor fabrication are enabling the integration of a large number of biological recognition elements within a single package. As a result, hundreds to millions of tests can be performed simultaneously and can facilitate rapid detection of multiple pathogens in a given sample. However, it is an open question as to how to exploit the high-dimensional nature of the multi-pathogen...
Wireless sensor networks (WSNs) are vulnerable to various attacks since they are distributed in unattended environments and have limited energy, storage and computation abilities. Preventive approaches can be applied to protect WSNs from some kinds of attacks. However, preventive methods are not efficient on specific attacks. So it is necessary to develop some mechanisms for intrusion detection. Intrusion...
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