The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
To pursue a new approach for discovering new side effects of drugs, we construct a drug-side effect network based on the SIDER2 database, and introducing link prediction methods in the network. We develop and evaluate the framework for drug side effect prediction based on link prediction in bipartite network. Integrating side effect appearance frequency has also been proved to be of value in improving...
Functional comparison and alignment of Protein Interaction Networks (PINs) will enable a better understanding of cellular organization and processes. Gene Ontology (GO) provides a structured standard vocabulary of functional terms of gene products, and has been used to measure the functional similarity between proteins. In this study, we propose an algorithm to measure the functional similarity between...
Viruses are devastating pathogens of humans, animals, and plants and virus infection mechanism is an important subject of virology and pathology research. To further our understanding of how viruses use the resource of infected cells, we systematically tested virus-yeast PPI network for the effect of virus perturbation on host proteins. Two viruses used in our study interact with vastly different...
Hepatitis B virus (HBV) infected people are at high risk of death from cirrhosis of the liver and liver cancer. To overcome the drug-resistant challenge of current anti-HBV compounds, substances blocking host support proteins in HBV infection are becoming increasingly important. Comprehensive HBV-human interactome map, which describe gene-level interactions of HBV proteins with human proteins, may...
Model of different level's sub-chronic aluminum intoxication in chickens was established by continuous peritoneal injection of different gradient aluminum trichloride (AlCl3). The contents of Al, Fe, Zn, Mn, Ca and Cu in serum, spleen and bursa of Fabricius, the contents of Complement 3(C3), Complement 4(C4), Interleukin-2 (IL-2) and tumor necrosis factor (TNF-alpha) in serum were detected. The results...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.