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What is known and objectiveVariation of the cytochrome P450 2C19 gene coding for the CYP2C19 enzyme has been reported to be associated with clopidogrel response variability. The activity of the CYP2C19 enzyme is genetically influenced by polymorphisms of its gene.
MethodsThis study was conducted to assess the impact of CYP2C19 polymorphism on the clopidogrel metabolism, indirectly selecting the plasma...
Although the involvement of insulin‐like signaling in cancer has been well documented in various types of cancers, the association between the genetic variants in the insulin‐like signaling and the development of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) remains unclear. In this study, a total of 498 individuals including 173 HBV related cirrhosis patients, 171 HBV‐related HCC...
ObjectivesCD14 is a causative gene for periodontitis. However, conflicting results had been achieved when evaluating the associations between CD14 −159 C>T and periodontitis, which warranted us to conduct this meta‐analysis.
Material and MethodsA meta‐analysis based on eight relevant case–control studies was conducted to address this issue. Odds ratios (OR) with 95% confidence intervals (CIs)...
Transferrin (TF) polymorphism was investigated in a color variety of goldfish (Carassius auratus), and its molecular basis analyzed. Three TF variants (A1, A2 and B1) were identified from an inbred strain of the goldfish, of which A1 and B1 displayed a large electrophoretic difference on both native and SDS-PAGE gels. The TF cDNAs corresponding to variants A1 and B1 were cloned and sequenced from...
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