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A fundamental trait of depression is low motivation. Hippocampal neurogenesis has been associated with motivational deficits but detailed evidence on how it regulates human‐relevant behavioral traits is still missing. We used the hGFAP‐TK rat model to deplete actively dividing neural stem cells in the rat hippocampus. Use of the effort‐discounting operant task allowed us to identify specific and detailed...
Neurobiological studies of memory typically involve single learning sessions that last minutes or days. In natural settings, however, animals are constantly learning. Here we investigated how several weeks of spatial water maze training influences subsequent activation of neocortical and hippocampal subregions, including adult-born neurons. Mice were either trained in a single context or in a variant...
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