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Retrotransposons have played a central role in human genome evolution. The accumulation of heritable L1, Alu and SVA retrotransposon insertions continues to generate structural variation within and between populations, and can result in spontaneous genetic disease. Recent works have reported somatic L1 retrotransposition in tumours, which in some cases may contribute to oncogenesis. Intriguingly,...
Pasteurella multocida toxin (PMT) is an AB toxin that causes pleiotropic effects in targeted host cells. The N‐terminus of PMT (PMT‐N) is considered to harbor the membrane receptor binding and translocation domains responsible for mediating cellular entry and delivery of the C‐terminal catalytic domain into the host cytosol. Previous studies have implicated gangliosides as the host receptors for PMT...
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