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RU58841, a new nonsteroidal antiandrogen from Roussel Uclaf, Romainville, France, has been tested for inhibiting the androgen receptor (AR) in human hair follicles (HF). AR has been localized in HF and found to play a major role in androgenetic alopecia, as well as hirsutism. RU58841 displayed a promising activity profile when tested with AR purified from HF, giving a calculated K i 0.4...
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