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BackgroundPro‐inflammatory cytokines and chemokines produced by activated keratinocytes play an important role in the pathogenesis of canine atopic dermatitis (AD) as well as human AD. Recent studies suggest that keratinocytes activated by IL‐17A are involved in the pathogenesis of human AD. However, the role of IL‐17A in canine keratinocytes is poorly understood.
Hypothesis/objectivesInterleukin‐17A...
BackgroundA previous study demonstrated that the cysteine protease of Dermatophagoides farinae induced production of granulocyte–macrophage colony‐stimulating factor (GM‐CSF) in a canine epidermal keratinocyte progenitor cell line (CPEK); however, the molecular mechanism has not been elucidated.
Hypothesis/ObjectivesGiven that the transcription of GM‐CSF mRNA in human lymphocytes is mainly regulated...