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For decades, Fast Scan Cyclic Voltammetry (FSCV) has been an established method for investigating neurochemical changes in animal models. Various neurotransmitters have been monitored successfully in vivo with high spatial and temporal resolution including dopamine, norepinephrine, adenosine, and serotonin. While FSCV has already provided myriad insights into physiological and pathophysiological neurochemical...
Thalamic deep brain stimulation (DBS) is an FDA-approved neurosurgical treatment for medication-refractory essential tremor. Its therapeutic benefit is highly dependent upon stimulation frequency and voltage parameters. We investigated these stimulation parameter-dependent effects on neural network activation by performing functional magnetic resonance imaging (fMRI) during DBS of the ventral lateral...
Summary Although most prenatally diagnosed anatomic malformations are best managed after birth, we can presently offer prenatal therapy to an increasing number of fetuses with simple anatomical defects that have predictably devastating developmental consequences. A condition amenable to prenatal intervention must fulfill a number of conditions. It must be severe enough to warrant the risks associated...
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