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Firms in developing countries can learn advanced technology and management know‐how through foreign direct investment (FDI). The extent (or the lack) of transmission of technology and knowledge depends on the structure of production networks. In the automotive industry, networks consist of vehicle assemblers and their layers of parts suppliers. We used the South African automotive industry as a case...
Glutamine tract expansion triggers nine neurodegenerative diseases by conferring toxic properties to the mutant protein. In SCA1, phosphorylation of ATXN1 at Ser776 is thought to be key for pathogenesis. Here, we show that replacing Ser776 with a phosphomimicking Asp converted ATXN1 with a wild-type glutamine tract into a pathogenic protein. ATXN1[30Q]-D776-induced disease in Purkinje cells shared...
Survival in highly competitive and fragmented markets requires producers to focus on both price and non-price factors such as quality, innovation, adherence to standards and rapid response as the basis for competitive advantage. In an effort to meet these new demands firms are deploying a range of innovations including advanced equipment and reconfiguration of both their internal organisation and...
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