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Mitochondria and intermediate filament (IF) accumulations often occur during imbalanced axonal transport leading to various types of neurological diseases. It is still poorly understood whether a link between neuronal IFs and mitochondrial mobility exist. In Caenorhabditis elegans, among the 11 cytoplasmic IF family proteins, IFB‐1 is of particular interest as it is expressed in a subset of sensory...
Model organisms are increasingly used to study and understand how neurofilament (NF)‐based neurological diseases develop. However, whether a NF homolog exists in C. elegans remains unclear. We characterize TAG‐63 as a NF‐like protein with sequence homologies to human NEFH carrying various coiled coils as well as clustered phosphorylation sites. TAG‐63 also exhibits features of NFL such as a molecular...
Bidirectional cargo transport in neurons can be explained by two models: the “tug‐of‐war model” for short‐range transport, in which several kinesin and dynein motors are bound to the same cargo but travel in opposing directions, and by the “motor coordination model” for long‐range transport, in which small adaptors or the cargo itself activates or deactivates opposing motors. Direct interactions between...
Kinesin‐3 UNC‐104(KIF1A) is the major axonal transporter of synaptic vesicles. Employing yeast two‐hybrid and co‐immunoprecipitation (Co‐IP) assays, we characterized a LIN‐2(CASK) binding site overlapping with that of reported UNC‐104 activator protein SYD‐2(Liprin‐α) on the motor's stalk domain. We identified the L27 and GUK domains of LIN‐2 to be the most critical interaction domains for UNC‐104...
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