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The present study aims to discover the influences of tamoxifen and 17β‐estradiol (E2) on tamoxifen‐resistant (TamR) patients in vitro. Herein, we established a stabilized TamR MCF‐7 cell line at 1 μM via gradient concentrations of tamoxifen cultivation. The expression changes of four ER subtypes (ERα66, ERβ, ERα36 and GPR30) were found to bring about tamoxifen resistance. Moreover, the generation...
Tamoxifen was widely applied in the therapy of estrogen receptor (ER)‐positive breast cancer. With the purpose of determining the potential impacts of quercetin on its effectiveness, MCF‐7 cells were selected as the in vitro model and several cellular biological behaviors (ie, cell proliferation, migration, invasion, cycle, apoptosis, and oxidative stress) were investigated. As results, quercetin...
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