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Key points
Spike doublets comprise ∼10% of in vivo complex spike events under spontaneous conditions and ∼20% (up to 50%) under evoked conditions.
Under near‐physiological slice conditions, single complex spikes do not induce parallel fibre long‐term depression.
Doublet stimulation is required to induce long‐term depression with an optimal parallel‐fibre to first‐complex‐spike timing interval of...
Motility of mitochondria, as well as their activity-dependent immobilization (“trapping”), is essential for neuronal function, but its regulation by cytoskeleton and relevance for glial cell signalling are unknown. Using time-lapse fluorescence imaging in rat cultured astrocytes, we evaluated the role of microtubules and actin filaments in motility of mitochondria in resting cells and during physiological...
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