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Key points
Arrhythmias result from disruptions to cardiac electrical activity, although the factors that control cellular action potentials are incompletely understood.
We combined mathematical modelling with experiments in heart cells from guinea pigs to determine how cellular electrical activity is regulated.
A mismatch between modelling predictions and the experimental results allowed us to construct...
Cardiac alternans, a putative trigger event for cardiac reentry, is a beat-to-beat alternation in membrane potential and calcium transient. Alternans was originally attributed to instabilities in transmembrane ion channel dynamics (i.e., the voltage mechanism). As of this writing, the predominant view is that instabilities in subcellular calcium handling are the main underlying mechanism. That being...
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