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Exposure to psychostimulant drugs of abuse such as amphetamine can result in long-lasting “sensitization” of reward-directed behavior, such that subjects display enhancements in behavior directed by and toward rewards and reward-predictive cues (i.e. “incentive sensitization”). The purpose of these experiments was to determine the degree to which such sensitization resulting from chronic amphetamine...
Rationale Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: “sign-tracking” (approach toward and contact with the cue) and “goal-tracking” (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving compulsive reward-seeking, such as addiction. Prior exposure to psychostimulant...
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