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DNA Origami
In article number 2308776, Chalmers Chau, Christoph Wälti, and co‐workers introduce the use of solid‐phase reversible immobilization (SPRI) beads as a scalable, high‐throughput, and automatable purification method to scale up the production of DNA origami nanostructures, with the aid of liquid handling robot. This artwork illustrates a DNA origami structure in the center and below a robot...
DNA origami synthesis is a well‐established technique with wide‐ranging applications. In most cases, the synthesized origami must be purified to remove excess materials such as DNA oligos and other functional molecules. While several purification techniques are routinely used, all have limitations, and cannot be integrated with robotic systems. Here the use of solid‐phase reversible immobilization...
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