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Primary cancer modulates the bone microenvironment to sow the seeds of dormancy and metastasis in tumor cells, leading to multiple organ metastasis and death. In this study, 3D printing and bone‐on‐a‐chip (BOC) are combined to develop a BOC platform that mimics the pre‐metastatic niches (PMNs) and facilitates elucidation of the interactions between bone‐resident cells and metastatic tumor cells under...
Current osteochondral (OC) defect repair approaches using premade scaffolds face clinical limitations due to invasiveness, weak integrity, and/or insufficient interfacial bonding. An injectable hydrophobic laminous adhesive is developed that rapidly photocross‐link subaqueously and forms robust bi‐layered structure that orchestrates biophysical‐chemical cues for stimulating OC repair. Liquid hydrophobic...
Electrosprayed microspheres for bone regeneration are conventionally restricted by the lack of osteogenic modulation for both encapsulated stem cells and surrounding cells at the defect site. Here, sodium alginate microspheres encapsulating L‐arginine doped hydroxyapatite nanoparticles (Arg/HA NPs) and bone mesenchymal stem cells (BMSCs) as regeneration‐enhancer‐element reservoirs (Arg/HA‐SA@BMSC)...
Bone Tissue Repair
In article number 2200314, Xin Zhao and co‐workers electrospray microspheres encapsulating stem cells and natural tissue metabolites as regeneration‐enhancer‐element reservoirs to power the inside/outside microsphere cell–cell/cell–material communication for accelerated vascularized bone tissue repair.
Recovery from bone, osteochondral, and cartilage injuries/diseases has been burdensome owing to the damaged vasculature of large defects and/or avascular nature of cartilage leading to a lack of nutrients and supplying cells. However, traditional means of treatment such as microfractures and cell‐based therapy only display limited efficacy due to the inability to ensure cell survival and potential...
Existing artificial periostea faces difficulty in supporting the entire bone repair cycle due to the absence of adhesion‐centric design and effective cell manipulation, leading to poor inhibition of soft tissue infiltration and induction of osteogenesis and angiogenesis. Here, a Janus periosteum with interior surface adhesion and exterior anatomical patterns to mimic the structure and function of...
Current periosteal grafts have limitations related to low mechanical strength, tissue adhesiveness, and poor osteogenesis and angiogenesis potential. Here, a periosteum mimicking bone aid (PMBA) with similar structure and function to natural periosteum is developed by electrospinning photocrosslinkable methacrylated gelatin (GelMA), l‐arginine‐based unsaturated poly(ester amide) (Arg‐UPEA), and methacrylated...
In article number 2000546, Jiankang He, Xin Zhao, and co‐workers report a human‐on‐leaf#x02010;chip system with biomimetic multiscale vasculature systems connecting vascularized organs, mimicking the complex in vivo architectures of the human cardiovascular system. The native organ‐to‐organ crosstalk is well recapitulated, implicating a strong potential for harnessing the leaf chip for circulatory‐related...
The vascular network is a central component of the organ‐on‐a‐chip system to build a 3D physiological microenvironment with controlled physical and biochemical variables. Inspired by ubiquitous biological systems such as leaf venation and circulatory systems, a fabrication strategy is devised to develop a biomimetic vascular system integrated with freely designed chambers, which function as niches...
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