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The A‐minor interaction, formed between single‐stranded adenosines and the minor groove of a receptor helix, is among the most common motifs found in rRNA. Among the A‐minors found in 16S rRNA are a set of interactions between adenosines at positions 1433, 1434 and 1468 in helix 44 (h44) and their receptors in the nucleotide 320–340 region of helix 13 (h13). These interactions have been implicated...
Mycobacterium tuberculosis is the causative agent of human tuberculosis (TB). Mycobacterial secretory protein ESAT‐6 induces matrix metalloproteinase (MMP)‐9 in epithelial cells neighboring infected macrophages. MMP‐9 then enhances recruitment of uninfected macrophages, which contribute to nascent granuloma maturation and bacterial growth. Disruption of MMP‐9 function attenuates granuloma formation...
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