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In article number 1900918, Deborah F. Kelly and co‐workers develop a new cryo‐electron microscopy (EM)‐on‐a‐chip approach. This strategy enables researchers to directly visualize the “fault in our stars” regarding cancer proteins. The structural assemblies of p53 from brain cancer cells are determined for the first time using the microchip‐based technique. Artistic rendition by Daryl N. Branford....
The fight against human disease requires a multidisciplinary scientific approach. Applying tools from seemingly unrelated areas, such as materials science and molecular biology, researchers can overcome long‐standing challenges to improve knowledge of molecular pathologies. Here, custom‐designed substrates composed of silicon nitride (SiN) are used to study the 3D attributes of tumor suppressor proteins...
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