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In article number 1803428, Jian Lin and co‐workers report the discovery of a novel self‐assembled metal protein nanoparticle, designated GST‐MT‐3, which targets the mitochondria of cancer cells within 30 min in vitro and rapidly accumulates in tumors within 1 h in vivo. The little men carrying the bombs represent GST‐MT3 protein nanoparticles loading the cobalt ions. Through the blood vessels they...
Self‐assembled protein nanoparticles have attracted much attention in biomedicine because of their biocompatibility and biodegradability. Protein nanoparticles have become widely utilized as diagnostic or therapeutic agents for various cancers. However, there are no reports that protein nanoparticles can specifically target mitochondria. This targeting is desirable, since mitochondria are critical...
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