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The Bayesian information criterion (BIC) can be useful for model selection within multilevel-modeling studies. However, the formula for the BIC requires a value for sample size, which is unclear in multilevel models, since sample size is observed for at least two levels. In the present study, we used simulated data to evaluate the rate of false positives and the power when the level 1 sample size,...
This paper addresses model‐based Bayesian inference in the analysis of data arising from bioassay experiments. In such experiments, increasing doses of a chemical substance are given to treatment groups (usually rats or mice) for a fixed period of time (usually 2 years). The goal of such an experiment is to determine whether an increased dosage of the chemical is associated with increased probability...
Many signaling circuits face a fundamental tradeoff between accelerating their response speed while maintaining final levels below a cytotoxic threshold. Here, we describe a transcriptional circuitry that dynamically converts signaling inputs into faster rates without amplifying final equilibrium levels. Using time-lapse microscopy, we find that transcriptional activators accelerate human cytomegalovirus...
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