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Recent studies have shown that expression levels of different alleles at the same HLA class I locus can vary dramatically, which might have a broad influence on human disease. However, precise quantification of the relative expression level of each HLA allele is challenging, because distinguishing different alleles on the same locus is difficult. Here, we developed a series of allele‐specific, real‐time...
Genetic architecture of asthma remains obscure. This study aimed to investigate whether the genetic polymorphisms of CDHR3 (rs6967330), GSDMB (rs2305480), IL33 rs928413, RAD50 (rs6871536) and IL1RL1 (rs1558641) are associated with the development of atopic asthma in Chinese population. Genotype and allele frequencies were compared between 516 patients and 552 controls by Chi‐square test. Patients...
We performed Killer cell immunoglobulin‐like receptor (KIR) genotyping on 1271 individuals of Chinese Han origin including 102 families and 965 unrelated individuals. The families (with one child and both parents) were subjected for haplotype analysis. Forty‐one different genotypes were identified. The frequencies of the KIR genotypes found in the family panel were confirmed by those found in the...
Trichloroethylene (TCE)‐induced hypersensitivity dermatitis is one of the critical occupational diseases among workers in China. Our previous studies have identified a strong linkage between the disease and the HLA‐B*13:01 allele. In this study, we searched for peptides bound to the HLA‐B*13:01 molecule; 57 HLA‐B*13:01‐bound peptides in total were identified and 54 peptides were used to calculate...
The human leukocyte antigen G (HLA‐G) molecule, a non‐classical major histocompatibility complex class I antigen, exhibits highly limited tissue distribution and gene variation. Recent studies indicate strong immunoinhibitory properties in tumor cells that may favor their escape from anti‐tumor immune responses. However, the role of HLA‐G in cervical premalignant and malignant lesions has not been...
The new alleles human leukocyte antigen (HLA)‐B*40:122 and HLA‐B*40:127 differs from B*40:02:01 and B*40:06:01:01 by a single nucleotide, respectively.
Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There is strong evidence suggesting a genetic susceptibility in individuals affected by keloids including familial heritability, common occurrence in twins, and high prevalence in certain ethnic populations. Human leukocyte antigens (HLAs) have been proposed to modulate the immune response...
The new human leukocyte antigen (HLA) class I allele, HLA‐Cw*0134, was identified in a Chinese individual. HLA‐Cw*0134 differs from HLA‐Cw*0124 by one nonsynonymous nucleotide change at the codon 99 (TGT to TAT) and one synonymous nucleotide change at the codon 127 (AAC to AAT).
Abstract
Down‐regulated expression of human leukocyte antigen (HLA) class I molecules in many human cancers facilitate tumor cells to escape from immune attack. Promoter hypermethylation, one of the major epigenetic changes responsible for gene inactivation, plays an important role in gastric carcinogenesis. This study evaluated the expression and alteration of HLA class I molecules in a panel of...
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