Search results for: Rhys Hamon

Items from 1 to 5 out of 5 results

article

Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis

Miranda P. Ween, Rhys Hamon, Matthew G. Macowan, Leigh Thredgold, more

Background and objective E‐cigarettes are often marketed and thought of as emitting harmless vapour; however, verification of their safety for non‐smokers is scarce. We have previously shown that E‐cigarettes cause decreased phagocytosis of bacteria by macrophages via reductions in surface bacterial recognition receptors. This study assessed the effect of E‐cigarette constituents, 3 E‐liquid apple...

article

Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children

Sandra Hodge, Matthew Macowan, Hong Liu, Rhys Hamon, more

Pediatric Pulmonology > 55 > 6 > 1414 - 1423

Aim Protracted bacterial bronchitis (PBB) is considered a potential precursor to bronchiectasis (BE) in some children. We previously showed that alveolar macrophages (AM) from children with PBB or BE have a similar significant defect in phagocytic capacity, with proinflammatory associations. We hypothesized that the mechanisms responsible for this defect involve dysregulation of the sphingosine‐1‐phosphate...

article

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD

Eugene Roscioli, Rhys Hamon, Susan E. Lester, Hubertus P. A. Jersmann, more

Respiratory Research > 2018 > 19 > 1 > 1-13

Background Individuals with respiratory disease are being increasingly exposed to wildfire smoke as populations encroach further into forested regions and climate change continues to bring higher temperatures with lower rainfall. Frequent exposures have significant potential to accelerate conditions such as chronic obstructive pulmonary disease (COPD) which is characterised by an exaggerated inflammatory...

article

X‐linked inhibitor of apoptosis single nucleotide polymorphisms and copy number variation are not risk factors for asthma

Eugene Roscioli, Rhys Hamon, Richard E. Ruffin, Peter Zalewski, more

Respirology > 18 > 4 > 697 - 703

Background and objectiveAberrant apoptosis in asthma contributes to airway inflammation. Early apoptosis and fragility of airway epithelial cells and delayed apoptosis of inflammatory lymphocytes can cooperate to increase airway inflammation. In this study, single nucleotide polymorphisms (SNPs) and copy number variation (CNV) in the Baculoviral inhibitor of apoptosis protein repeat‐containing 4 (...

article

Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways

Eugene Roscioli, Rhys Hamon, Susan Lester, Chiara Murgia, more

BioMetals > 2013 > 26 > 2 > 205-227

Integrity of the airway epithelium (AE) is important in the context of inhaled allergens and noxious substances, particularly during asthma-related airway inflammation where there is increased vulnerability of the AE to cell death. Apoptosis involves a number of signaling pathways which activate procaspases leading to cleavage of critical substrates. Understanding the factors which regulate AE caspases...

Filter options

Publication date

Set your own date range

Keywords

AIRWAY EPITHELIUM (2)
APOPTOSIS (2)
ASTHMA (2)
INFLAMMATION (2)
AIRWAYS (1)
BARRIER FUNCTION (1)
BRONCHIECTASIS (1)
CHILDHOOD LUNG DISEASE (1)
CIGARETTE SMOKE (1)
COPD (1)
COPY NUMBER VARIATION (1)
CYTOKINES (1)
EFFEROCYTOSIS (1)
ENVIRONMENTAL HEALTH (1)
EXACERBATION (1)
E‐CIGARETTES (1)
GENETIC (1)
HAEMOPHILUS INFLUENZAE (1)
MACROPHAGES (1)
PHAGOCYTOSIS (1)
PROTRACTED BACTERIAL BRONCHITIS (1)
SINGLE NUCLEOTIDE POLYMORPHISMS (1)
SPHINGOSINE‐1‐PHOSPHATE (S1P) (1)
WILDFIRE (1)
X‐LINKED INHIBITOR OF APOPTOSIS PROTEIN (1)
ZINC (1)
more

Data set

Wiley (3)
Springer (2)

INFONA - science communication portal

Search results for: Rhys Hamon

Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis

Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD

X‐linked inhibitor of apoptosis single nucleotide polymorphisms and copy number variation are not risk factors for asthma

Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Rhys Hamon

Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis

Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD

X‐linked inhibitor of apoptosis single nucleotide polymorphisms and copy number variation are not risk factors for asthma

Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options