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Abnormal activation of β‐catenin has been reported in 90% in the sporadic and hereditary colorectal cancer. The suppression of abnormally activated β‐catenin is one of the good strategies for chemoprevention and treatment of colorectal cancer. In this study, we have isolated two main compounds from root of Saussurea lappa, dehydrocostus lactone (DCL) and costunolide (CL), and investigated their anti‐colorectal...