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Background
The objective of this study was to determine whether PC‐3 human prostate cancer cell‐derived cancer stem cells (CSC)‐like cells grown in a regular cell culture plate not coated with a matrix molecule might be useful for finding differentiation‐inducing agents that could alter properties of prostate CSC.
Methods
Monolayer cells prepared from sphere culture of PC‐3 cells were characterized...
Cancer is one of the deadliest diseases in the world. Despite extensive studies, treating metastatic cancers remains challenging. Years of research have linked a rare set of cells known as cancer stem cells (CSCs) to drug resistance, leading to the suggestion that eradication of CSCs might be an effective therapeutic strategy. However, few drug candidates are active against CSCs. New drug discovery...
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