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BACKGROUNDProstate‐specific membrane antigen (PSMA) remains an active target for imaging and therapeutic applications for prostate cancer.
METHODSIn the present study, an irreversible phosphoramidate inhibitor, CTT‐54 (IC50 = 14 nM), has been modified to deliver 99mTc‐(CO)3‐DTPA as a SPECT imaging payload to PSMA+ cells in vivo and in vitro. Percent uptake, competitive binding, and internalization...