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The enzyme Arylsulfatase B (ARSB; N‐acetylgalactosamine‐4‐sulfatase) removes 4‐sulfate groups from chondroitin‐4‐sulfate and dermatan sulfate and is required for the degradation of these sulfated glycosaminoglycans (sGAGs). Since these GAGs accumulate in patients with Cystic Fibrosis (CF), we investigated the activity of ARSB in leukocytes of patients with CF, to consider if reduced activity of ARSB...