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Background Continuous beta-agonist therapy, typically in the form of inhaled albuterol, is the first line therapy for the treatment of acute and severe bronchospasm in children. Although this treatment is commonly used, concerns about cardiotoxicity have been raised. We aimed to investigate the cardiotoxic effects of continuous beta-agonist therapy in children. Methods We conducted a retrospective...
BackgroundDuring severe exacerbations, asthmatic children vary significantly in their response to high‐dose continuous β2‐adrenergic receptor (ADRβ2) agonist therapy. Genetic polymorphisms have been identified within the ADRβ2 that may be functionally relevant, but few studies have been performed in this population. Our hypothesis was that genotypic differences are associated with magnitude of response...
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