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DOI: 10.1002/pmic.201500374
In the cover image, Xiaobo Yu et al. use traffic signals to echo the images of the protein arrays both to capture the notion of accelerating discovery and capture the notion that arrays are used to understand signaling. For more details, see the article by Xiaobo Yu et al. on page 1238.
Protein microarrays are a high‐throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective,...
A novel quantification method is proposed for labeled LC-MS data. Unlike the traditional extracted ion chromatogram based quantification methods, the new method considers the reliability or the quality of signals with different intensities and applies more weights to the more reliable signals in the relative quantification procedure. Testing shows that the new method has improved accuracy than current...
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