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Thromboembolism is a serious toxicity in the treatment of acute lymphoblastic leukemia (ALL), but little is known about the correlation between asparaginase enzyme activity (ASA) levels and coagulation parameters. We included 65 non‐high risk ALL patients, aged 1–17 years. Coagulation parameters and corresponding ASA levels were measured during asparaginase treatment. We found ASA to be negatively...
Background
As pegylated asparaginase is becoming the preferred first‐line asparaginase preparation in the chemotherapy regimens of childhood acute lymphoblastic leukemia (ALL), there is a need to evaluate this treatment.
Methods
The aim of this study was to evaluate the pharmacokinetics of prolonged upfront biweekly PEG‐asparaginase (where PEG is polyethylene glycol) treatment by measuring serum...
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