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BackgroundHepatic veno‐occlusive disease (VOD) is a rare and potentially severe complication of chemotherapy. We describe five patients who developed VOD after chemotherapy for Wilms tumor (WT) and evaluate the role of plasminogen activator inhibitor‐1 (PAI‐1) and defibrotide for diagnosis and therapy of VOD, respectively.
Patients and methodsThirty‐five patients treated from 2002 to 2009 for WT...
Introduction We report a simplified method of performing antibiotic lock therapy (ALT) based on a disposable central venous catheter (CVC) hub device, CLC 2000, enabling an open-ended CVC to be flushed with normal saline solution without heparin. Methods ALT was administered through a CLC 2000 connector for recurrent CVC-bloodstream infections (BSI) by the same organism in four patients and for...
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